Christa Brosseau

Associate Professor
Faculty of Science
Chemistry

Faculty Member Information

Interests

Research is focused on using analytical tools to study the chemical biophysics of systems implicated in human disease. Current studies are focused on protein-protein and protein-membrane systems, with an emphasis on protein aggregation disorders, including Alzheimer's and Parkinson's disease. Specifically, research includes: Interfacial electrochemistry, bioelectrochemistry of proteins and biomembrane systems, plasmonic nanoarray electrode design and engineering for surface-enhanced vibrational spectroscopies. Interfacial electrochemistry, Plasmonics, Surface Vibrational Spectroscopy, Nanotechnology, Analytical and Biophysical Chemistry

Education

Ph.D., , University of Guelph, 2007
M.S., , Acadia University, 2003
B.S., , Dalhousie University , 2001

Academic Work Experience

2009 - Present, Associate Professor (Tenured), Department of Chemistry

Membership

2015 - Present, American Chemical Society (ACS)
2015 - Present, Canadian Institute of Chemistry (CIC)
2015 - Present, International Society of Electrochemistry (ISE)
2015 - Present, Electrochemical Society (ECS) –Secretary of Canadian section

Honours

Discovery Award – Emerging Professional, 2013 Discovery Awards, Halifax NS - 2013
SMUSA Faculty of Science Teaching Excellence Award Saint Mary’s University - 2010

Teaching: Course / Program Development

2008/03 - Present, Teaching Experience

Scholarly Contributions

Journal Articles

Zhao L, Harroun S, Clarke O, Blackburn J, Brosseau Christa. "Development of a Plasmonic Aptasensor for the direct detection of heme protein at the point-of-care" (Spring - 2015)
Clarke O, Brosseau Christa. "Electrochemical SERS For Improved Sensing of Protein Aggregation Phenomena" (Spring - 2015)
Robinson A, Harroun S, Brosseau Christa. "Effect of Chloride Ion on Self-Assembled Monolayer Formation on Silver" (Spring - 2015)
Robinson A, Zhao L, Yasmin P, Bhandari P, Harroun S, Dendukuri J, Blackburn C, Brosseau Christa. "The development of “Fab-Chips” as low-cost, sensitive surface-enhanced Raman spectroscopy (SERS) substrates for prospective disease diagnosis", Analyst 140:3 (Spring - 2015), p.779
Merchant S, Karaballi R, Power S, Suteanu M, Robinson A, Brosseau Christa. "Spectroelectrochemical Studies of Protein Aggregate – Biomembrane Interactions" (Spring - 2015)
Karaballi R, Nel A, Krishnan J, Blackburn J, Brosseau Christa. "Development of an Electrochemical Surface-Enhanced Raman Spectroscopy (EC-SERS) Aptasensor for Direct Detection of DNA Hybridization", Physical Chemistry Chemical Physics (Spring - 2015)
Lamsal R, Brosseau Christa, Harroun S, Bergman J, Walsh M, Brosseau C, Gagnon G. "Use of Raman and Surface-Enhanced Raman Spectroscopy for Membrane Fouling Studies" (Spring - 2015)
Zhao L, Blackburn J, Brosseau Christa. "Quantitative Detection of Uric Acid by Electrochemical-Surface Enhanced Raman Spectroscopy (EC-SERS) Using a Multilayered Au/Ag Substrate", Analytical Chemistry 87:1 (Spring - 2015), p.441
Murphy L, Robertson K, Harroun S, Brosseau Christa, Werner-Zwanziger U, Moilanen J, Tuononen J, Clyburne J. "A Simple Complex on the Verge of Breakdown: Isolation of the Elusive Cyanoformate Ion", Science 344:6179 (Spring - 2014), p.75
Leitch J, Brosseau Christa, Roscoe S, Bessonov K, Dutcher J, Lipkowski J. "Electrochemical and PM-IRRAS Characterization of Cholera Toxin Binding at a Model Biological Membrane", Langmuir 29 (Spring - 2013), 965
Goodall B, Robinson A, Brosseau Christa. "Electrochemical-Surface Enhanced Raman Spectroscopy (E-SERS) of uric acid: A Potential Rapid Diagnostic Method for Early Preeclampsia Detection", Physical Chemistry Chemical Physics 15 (Spring - 2013), p.1382
Harroun S, Abraham T, Prudhoe C, Zhang Y, Scammells P, Brosseau Christa, Pye C, Singer R. "Electrochemical Surface-Enhanced Raman Spectroscopy (E-SERS) of Novel Biodegradable Ionic Liquids", Physical Chemistry Chemical Physics 15:44 (Spring - 2013), p.19205
Vezvaie M, Brosseau Christa, Lipkowski J. "Electrochemical SERS Study of a Biomimetic Membrane Supported at a Nanocavity Patterned Ag Electrode", Electrochemica Acta 110 (Spring - 2013), p.120
Robinson A, Harroun S, Bergman J, Brosseau Christa. "A Portable Electrochemical SERS system for Routine Spectroelectrochemical Analysis", Analytical Chemistry 84 (Spring - 2012), p.1760
Lamsal R, Harroun S, Brosseau Christa, Gagnon G. "Use of Surface Enhanced Raman Spectroscopy for Studying Fouling on Nanofiltration Membrane", Separation and Purification Technology 96 (Spring - 2012), p.7
Vezvaie M, Brosseau Christa, Goddard J, Lipkowski J. "Surface-enhanced Raman spectroscopy of -Thioglucose adsorbed on Nano-structured silver electrodes", Chemphyschem 11:7 (Spring - 2010), 1460
Brosseau Christa, Rayner K, Casadio F, Grzywacz C, Van Duyne R. "Surface-Enhanced Raman Spectroscopy: A Direct Method to Identify Colorants in Various Artist Media", Analytical Chemistry 81:17 (Spring - 2009), p.7443
Chen M, Li M, Brosseau Christa, Lipkowski J. "AFM Studies of the Effect of Temperature and Electric Field on the Structure of a DMPC-Cholesterol Bilayer Supported on a Au(111) Electrode Surface", Langmuir 25:2 (Spring - 2009), 1028
Brosseau Christa, Gambardella A, Casadio F, Grzywacz C, Wouters J, Van Duyne R. "Ad-Hoc SERS Methodologies for the Detection of Artist Dyestuffs: Thin Layer Chromatography – Surface-Enhanced Raman Spectroscopy (TLC-SERS) and In Situ On the Fiber Analysis", Analytical Chemistry 81:8 (Spring - 2009), p. 3056
Wustholz K, Brosseau Christa, Casadio F, Van Duyne R. "Surface-enhanced Raman spectroscopy of dyes: from single molecules to the artists’ canvas", Physical Chemistry Chemical Physics (Spring - 2009)
Li M, Chen M, Sheepwash E, Brosseau Christa, Li H-Q, Pettinger B, Gruler H, Lipkowski J. "AFM Studies of Solid-Supported Lipid Bilayers formed at a Au(111) Electrode Surface Using Vesicle Fusion and a Combination of Langmuir-Blodgett and Langmuir-Schaefer Techniques", Langmuir 24:18 (Spring - 2008), p. 10313
Brosseau Christa, Bin X, Roscoe S, Lipkowski J. "Electrochemical and PM-IRRAS Characterization of DMPC/Cholesterol Bilayers Prepared Using Langmuir-Blodgett / Langmuir-Schaefer Deposition", Journal of Electroanalytical Chemistry 621 (Spring - 2008), p. 222
Brosseau Christa, Leitch J, Bin X, Chen M, Roscoe S, Lipkowski J. "Electrochemical and PM-IRRAS Studies of a Glycolipid Containing Biomimetic Membrane Prepared using Langmuir Blodgett / Langmuir Schaefer Deposition", Langmuir 24:22 (Spring - 2008), p. 13058
Sek S, Brosseau Christa, Chen M, Lipkowski J. "In Situ STM Study of Field Driven Transitions in the Film of a Cationic Surfactant Adsorbed on a Au(111) Electrode Surface", Langmuir (COVER) 23 (Spring - 2007), p.12529
Brosseau Christa, Sheepwash E, Burgess I, Cholewa E, Lipkowski J, Roscoe S. "Adsorption of N-Decyl-N,N,N-Trimethyl Ammonium Triflate (DeTATf), A Model Cationic Surfactant, on the Au(111) Surface", Langmuir 23 (Spring - 2007), p. 1784
Brosseau Christa, Roscoe S. "Electrochemical Quartz Crystal Nanobalance and Chronocoulometry Studies of Phenylalanine Adsorption on Au", Electrochimica Acta 51:11 (Spring - 2006), p. 2145
Garcia-Araez N, Brosseau Christa, Rodriguez P, Lipkowski J. "Layer by layer Characterization of DMPC Bilayers Deposited on a Au(111) Electrode Surface by PM-IRRAS", Langmuir 22:25 (Spring - 2006), p. 10365
Brosseau Christa, Roscoe S. "Electrochemical Quartz Crystal Nanobalance (EQCN) Studies of the Adsorption Behaviour of an Enzyme, Mandelate Racemase, and its Substrate, Mandelic acid on Pt", Electrochimica Acta 50:6 (Spring - 2005), p. 1289
Wright J, Faith K, Brosseau Christa, Omanovic S, Roscoe S. "L-Phenylalanine Adsorption on Pt: Electrochemical Impedance Spectroscopy and Quartz Crystal Nanobalance Studies", Journal of Electroanalytical Chemistry 550 (Spring - 2003), p. 41

Presentation

Brosseau Christa, Merchant S, Karaballi R. "Spectroelectrochemical Studies of Protein Aggregate – Biomembrane Interactions", The Electrochemical Society Canadian Section, Spring Meeting (Spring - 2015)
Brosseau Christa, Zhao L, Karaballi R, Harroun S. "Plasmon-Enhanced Spectroelectrochemistry: An Advanced Tool for Biosensing", Surface Science Canada Meeting (Spring - 2015)
Blackburn J, Krishnan S, Dheda K, Gluckberg M, Van Duyne R, Khati M, Evans M, Brosseau Christa. "Development of a Novel Biosensing Platform for Rapid TB Detection at the Point-of-Care", Grand Challenges Meeting (Winter - 2012)
Brosseau Christa, Karaballi R, Nel A, Blackburn J. "Electrochemical SERS: A Tool for Rapid Detection of TB Biomarkers", The Electrochemical Society Canadian Section, Fall Meeting (Fall - 2012)
Brosseau Christa, Leitch J, Roscoe S, Lipkowski J. "Electrochemical PM-IRRAS Studies of Cholera Toxin Binding at a Model Biomembrane Surface", 2nd Ertl Symposium on Surface and Interface Chemistry (Spring - 2012)
Brosseau Christa. "Electrochemical Surface-Enhanced Raman Spectroscopy (E-SERS): A Plasmonic Tool for Biochemistry", Dalhousie University, Department of Biochemistry (Fall - 2012)
Brosseau Christa, Karaballi R, Nel A, Blackburn K. "Electrochemical SERS for Rapid Detection of TB Biomarkers", 63rd International Society of Electrochemistry Meeting (Summer - 2012)
Brosseau Christa, Yuen J, Krishnan S, Nel A, Karaballi R, Harroun S, Glucksberg M, Van Duyne R, Khati M, Evans M. "Development of a Hand-held DNA-aptamer based SERS Biosensor", Point-of-Care Diagnostics Meeting (Spring - 2012)
Harroun S, Bergman J, Jablonski E, Brosseau Christa. "Surface-enhanced Raman Spectroscopy of housepaint and wallpaper samples from an 18th century historic property", Chemcon APICS Conference (Spring - 2011)
Brosseau Christa, Harroun S, Abraham T, Scammells P, Singer R. "Portable Electrochemical SERS on a Shoestring Budget", Electrochemical society Canadian section meeting (Spring - 2011)
Clarke O, Brosseau Christa. "Detection of Proteins via Spectroelectrochemical Analysis", Chemcon APICS Conference (Spring - 2011)
Brosseau Christa. "New Frontiers in Surface-Enhanced Raman Spectroscopy", Dalhousie University, Department of Chemistry (Winter - 2011)
Brosseau Christa, Harroun S, Abraham T, Scammells P, Singer R. "Spectroelectrochemical studies of Novel Biodegradable Ionic Liquids", 219th The Electrochemical Society Meeting (Spring - 2011)
Brosseau Christa. "New Frontiers in Surface-Enhanced Raman Spectroscopy", APICS tour speaker (Fall - 2010)
Brosseau Christa, Casadio F, Van Duyne R. "Silver Nanoparticles and SERS: A Tool for Art Conservation", Gordon Research Conference (Spring - 2010)
Brosseau Christa, Casadio F, Van Duyne R. "Plasmonic Sensor Applications in Art Conservation", Productive Affinities: Successful Collaborations between Museums and Academia (Summer - 2009)
Brosseau Christa. "Surface-Enhanced Raman Spectroscopy: An analytical tool for art conservation", Thermo Electron Research Symposia Series on Vibrational Spectroscopy, (Spring - 2009)
Brosseau Christa. "SERS enters the Art Scene: Nanoscience as a Tool for Art Conservation", University of Guelph (Fall - 2009)
Brosseau Christa, Wustholz K, Greeneltch N, Van Duyne R. "Electrochemical and Surface-Enhanced Raman Spectroscopy Studies of the Adsorption of trans-1,2-bis(4-pyridyl)ethylene at a Silver Film-Over-Nanosphere (AgFON) Surface", American Chemical Society Fall Meeting (Summer - 2009)
Brosseau Christa. "Detecting Danger – Developing Electrochemical SERS as a tool for threat reduction", The Electrochemical Society Canadian section fall symposium (Fall - 2009)
Brosseau Christa. "Surface-Enhanced Raman Spectroscopy: A tool for the detection of artist dyestuffs", Society for Applied Spectroscopy, Workshop on Infrared and Raman Micro-spectroscopy (Spring - 2009)
Brosseau Christa, Roscoe S, Lipkowski J. "Spectroelectrochemical Studies of a Cholera Toxin Binding at a Model Biomembrane Surface", Chemical Biophysics Symposium (Spring - 2007)
Brosseau Christa, Roscoe S, Lipkowski J. "Electrochemical and PMIRRAS Studies of Cholera Toxin Binding at a Model Biomembrane Surface", 58th Annual Meeting of the International Society of Electrochemistry (Fall - 2007)
Brosseau Christa, Roscoe S, Lipkowski J. "Electrochemical and PMIRRAS Studies of Cholera Toxin Binding at a Model Biomembrane Surface", 90th Conference of the Canadian Society for Chemistry (Spring - 2007)
Brosseau Christa, Roscoe S, Lipkowski J. "PMIRRAS Characterization of Cholera Toxin Binding at a Biomimetic Membrane Surface", Thermo Fisher Research Symposia Series on Vibrational Spectroscopy (Winter - 2007)
Brosseau Christa, Roscoe S, Lipkowski J. "Electrochemical and PMIRRAS Studies of a Model Biomimetic System at a Au(111) Surface", 89th Conference of the Canadian Society for Chemistry (Spring - 2006)
Brosseau Christa. "Polarization Modulation Infrared Reflection Absorption Spectroscopy (PMIRRAS): A Tool for In-Situ Biomimetic Studies", Thermo Electron Research Symposia Series on Vibrational Spectroscopy (Winter - 2006)
Brosseau Christa, Lipkowski J, Roscoe S. "Electrochemical and PMIRRAS Studies of a Phospholipid Bilayer Membrane at a Au(111) Surface", Chemical Biophysics Symposium (Spring - 2006)
Brosseau Christa, Lipkowski J, Roscoe S. "Electrochemical and PMIRRAS Studies of a Phospholipid Bilayer Membrane at a Au(111) Surface", The Electrochemical Society Canadian Section Fall Symposium (Fall - 2006)
Brosseau Christa, Lipkowski J, Roscoe S. "Electrochemical and PMIRRAS Studies of Cholera toxin – Membrane Interactions at the Au(111) Surface", The Electrochemical Society Canadian Section Spring Symposium (Spring - 2006)
Brosseau Christa, Sheepwash E, Burgess I, Lipkowski J, Roscoe S. "Adsorption of Decyltrimethylammonium Triflate (DeTATf), a Model Cationic Surfactant, on the Au(111) Surface", Roscoe, 207th The Electrochemical Society Meeting (Spring - 2005)
Brosseau Christa, Sheepwash E, Burgess I, Lipkowski J, Roscoe S. "Adsorption of Decyltrimethylammonium Triflate (DeTATf), a Model Cationic Surfactant, on the Au(111) Surface", 4th Annual Chemical Biophysics Symposium (Spring - 2005)
Brosseau Christa, Lipkowski J. "Electrochemical Studies of Supported Bilayer Membranes at the Au(111) Surface", The Electrochemical Society Young Authors Symposium (Summer - 2005)
Brosseau Christa, Roscoe S. "Analysis of the Adsorption Behavior of Mandelate Racemase and its Substrate: Comparison of Chronocoulometry and EQCN Techniques", 3rd Annual Chemical Biophysics Symposium (Winter - 2004)
Brosseau Christa, Lipkowski J. "Spectroelectrochemical Studies of DMPC Bilayers on Au(111)", The Electrochemical Society Young Authors Symposium (Spring - 2004)
Brosseau Christa, Roscoe S. "Analysis of the Adsorption Behaviour of Mandelate Racemase and its Substrate: Comparison of Chronocoulometry and EQCN Techniques", 39th International Union of Pure and Applied Chemistry Congress and the 86th Conference of the Canadian Society for Chemistry (Summer - 2003)
Brosseau Christa, Roscoe S. "Effect of Charge on Protein Adsorption", Biomedical Engineering Research Day (Spring - 2003)
Brosseau Christa, Roscoe S. "Analysis of the Adsorption Behavior of Mandelate Racemase and its Substrate: Comparison of Chronocoulometry and EQCN Techniques", 19th Annual Symposium on Chemical Physics (Fall - 2003)

Service: Institutional Committees

Served on search committee for tenure-track faculty position (organic chemistry) , 2012/02 - 2012/02 (672)
Served as program representative and chair for MSc thesis defense (Naomi Harper, August 2011), 2010/04 - 2010/04 (673)
Served on search committee for new departmental chair , 2010/02 - 2010/02 (671)
Served as IYC planning committee member , 2009/03 - None (669)
MSc committee member for Liwei Cheng (Dr. Cory Pye) , 2009/03 - None (670)

Service: Professional or Disciplinary

Helped organize public lecture and poster session for International Year of Chemistry , 2012/01 - 2012/01
Poster judge at Chemcon, Cape Breton University, Chemcon 2011/03 - 2011/03
Participated as a role model in the Techsploration program , 2011/03 - 2012/03
Poster judge at ECS Spring Symposium, Queens University, Electrochemical Society 2010/03 - 2010/03
Poster judge at Chemcon, UPEI, Chemcon 2010/03 - 2010/03
Poster judge at Chemcon, Dalhousie University, Chemcon Conferences 2009/03 - 2009/03
APICS tour speaker , APICS 2009/03 - 2010/03
Poster judge at ECS Fall Symposium, Dalhousie University, The Electrochemical Society 2009/01 - 2009/01

Biography

<p><span>Christa was born in Halifax, Nova Scotia and received a BSc degree in chemistry from Dalhousie University. Her MSc degree was completed in 2003 under the supervision of Prof. Sharon Roscoe at Acadia University, where she studied the adsorption of proteins on metallic surfaces using electrochemical methods. In 2007 she completed a PhD at the University of Guelph under the supervision of Prof. Jacek Lipkowski on a project which involved using electrochemistry and infrared spectroscopy to probe the interaction of cholera toxin with a model biological membrane supported on an electrode surface. In 2007 Christa moved to Evanston, Illinois to take up an Andrew W. Mellon Foundation postdoctoral fellowship at Northwestern University under the supervision of Prof. Richard P. Van Duyne, a project which, in collaboration with the Art Institute of Chicago, used surface-enhanced Raman spectroscopy (SERS) to analyze colorants in historical textiles and paintings. In 2009 Christa joined the Chemistry department at Saint Mary's University as an Assistant Professor, and is very excited to be back in the Maritimes!</span></p>