Faculty
Keith Vaughan, PhD 
Professor
B.Sc.Tech. (University of Manchester Institute for Science and Technology, Manchester, UK, 1964)
Ph.D. (Queen's College of St. Andrew's University, Dundee, Scotland,1967)
Research Interests
Nitrogen-containing Heterocycles; Triazenes; Bis-triazenes; NMR spectroscopy; Anti-cancer Drugs; Macrocyclic Chemistry.
Research
My research interests lie in the area of organic synthesis, specifically of nitrogen-containing heterocyclic and acyclic molecules with potential antitumour activity. Of special interest to me are the triazenes, which are known to be antitumour agents; some of the triazenes, notably DACARBAZINE and TEMOZOLOMIDE, are used clinically in the treatment of skin cancer and brain tumours. Currently we are investigating the synthesis of an extensive series of bis-triazenes derived from alkanediamines which have been shown to possess some novel properties. The NMR spectra of some of these molecules are quite novel, and several crystal structures of molecules in this series have revealed some unique structural features.
Teaching
Keith Vaughan, PhD 
Professor
B.Sc.Tech. (University of Manchester Institute for Science and Technology, Manchester, UK, 1964)
Ph.D. (Queen's College of St. Andrew's University, Dundee, Scotland,1967)
Teaching
My teaching expertise covers all levels of organic chemistry from the introductory course (CHEM 2344.1(.2)) to advanced organic chemistry
(CHEM3443.1/4444.2). I also teach first year Introductory Chemistry, Organic Spectroscopy (CHEM 3445.1(.2).
Student Research Groups
B.Sc.Tech. (University of Manchester Institute for Science and Technology, Manchester, UK, 1964)
Ph.D. (Queen's College of St. Andrew's University, Dundee, Scotland,1967)
Contact Information
Personal Web Site
Current Student Researchers: 
Erin McLeod
Christopher J. Walsh
Previous Student Researchers:
Chenguang Fan (2005)
Karen Schurman (2005)
Jeff Clarke (2004 and 2005)Naomi Hunter (2004 and 2005)
Vanessa Little (2003, 2004 and 2005)
Chris Corbeil (Honours Chemistry 2004)
Shasta Moser (2002 and 2003)
Reid Tingley (2002 and 2003)
Brad Peori (2002)
Patricia Szebezza (2002)
Robert Zalega (2001)
Julie Glister (Honours Chemistry 2000)
Elizabeth Turner (2000)
Publications
“An X-Ray Crystallographic Study of the Novel Aminal bis -(p-Ethoxycarbonylphenylamino-)methane.” By M. Brad Peori, Keith Vaughan and Valerio Bertolasi. Journal of Chemical Crystallography. 39 : 178-181 (2009).
"Crystal Structures of a Series of Bis{(2-aminobenzoyl-)amino}alkanes.” by Valerio Bertolasi, Naomi Hunter and Keith Vaughan . Journal of Chemical Crystallography, (2009), 39 (5), 372-376.
"An X-Ray Crystallographic Study of the Related Triazenes, 1,4-di[( E )-2-(2-nitrophenyl)-1-diazenyl]piperazine and Methyl 4-{(E)-2-(4-Methylpiperazino)-1-diazenyl}benzoate” by Vanessa Renee Little, Hilary Jenkins and Keith Vaughan *, J. Chem. Cryst. 38 , 447-452 (2008).
"Triazene Derivatives of (1,x)-Diazacycloalkanes. Part VIII. Synthesis and Characterization of a series of 1,4-Di[2-aryl-1-diazenyl]-2-methylpiperazines." by Naomi Hunter, Reid Tingley, Brad Peori and Keith Vaughan *, Canadian Journal of Chemistry, 85 , 189-196(2007).
“A Series of 1-[2-Aryl-1-diazenyl]-3-({3-[2-aryl-1-diazenyl]perhydro- benzo[d] imidazol-1 yl}methyl)perhydrobenzo[d]imidazoles". Synthesis and Characterization”. by Julie F. Glister and Keith Vaughan . Journal of Heterocyclic Chemistry, 43 , 217-222 (2006).
“Synthesis and Characterization of a Series of 1,x-bis-(4-Oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)alkanes.” by Naomi Hunter and Keith Vaughan . Journal of Heterocyclic Chemistry, 43 , 731-737(2006).
“Synthesis and Characterization of a series of 3-Methyl-3-{3-[1-methyl-3-aryl-2-triazenyl]propyl}-1-aryl-1-triazenes and related compounds.” by Jeff D. Clarke, Shasta L. Moser and Keith Vaughan *, Can. J. Chem. 84 , 831-842(2006).
“1-[2-(p-Tolyl)-1-diazenyl]-3-({3-[2-(p-tolyl)-1-diazenyl]perhydrobenzo[d] imidazol-1-yl}methyl)perhydrobenzo[d]imidazole. Synthesis, Characterization and X-ray crystal structure”.By Julie F. Glister, Hilary Jenkins and Keith Vaughan .* J. Chem. Cryst. 36 , 445-452 (2006).
“1,4,8,11-Tetra-[2-aryl-1-diazenyl-]1,4,8,11-tetraazacyclotetradecanes: Synthesis, Characterization and X-ray Crystallography of the first-ever tetrakis-Triazenes to be synthesized.” by Jeffery D. Clarke, Keith Vaughan and Valerio Bertolasi, Can. J. Chem. 84 , 1280-1289 (2006).
"Triazene Derivatives of (1,x-)Diazacycloalkanes. Part VIa 3-({5,5-Dimethyl-3-[2-aryl- 1-diazenyl]-1-imidazolidinyl}methyl)-4,4-dimethyl-1-[2-aryl-1-diazenyl] imidazolidines: Synthesis, Characterization and X-Ray Crystal Structure." Keith Vaughan *, Shasta Lee Moser, Reid Tingley, M. Brad Peori and Valerio Bertolasi. Can. J. Chem. 84 , 1294-1300 (2006).
"Triazene derivatives of (1,x)-diazacycloalkanes. Part VII. Synthesis of a series of 1-aryl-2-[3-(3-[2-aryl-1-diazenyl]-1,3-diazepan-1-ylmethyl)-1,3-diazepan-1-yl]-1-diazenes from the reaction of diazonium salts with mixtures of formaldehyde and 1,4-diaminobutane." by Reid Tingley and Keith Vaughan *. Canadian Journal of Chemistry, 84 , 1434-1441 (2006).
"X-Ray Crystal Structure determination of a series of 1-aryl-2-[3-(3-[2-aryl-1-diazenyl]-1,3-diazepan-1-ylmethyl)-1,3-diazepan-1-yl]-1-diazenes obtained from the reaction of diazonium salts with mixtures of formaldehyde and 1,4-diaminobutane." by Reid Tingley , Valerio Bertolasi and Keith Vaughan . Journal of Chemical Crystallography, 36 , 831-839 (2006).
"An ab initio Study of the SN2 Reaction of 1- and 3-Methyltriazene with Halide Ion." by K.G. Doucet, C.C. Pye*, K. Vaughan and T.G. Enright. Journal of Molecular Structure THEOCHEM. 801(2006) 21-28.
Conference Presentations
"An Ab Initio Study of 5-(1-Triazenyl)imidazole, a Simple Structural Analogue of the Antineoplastic Agent Dacarbazine". by C.C. Pye, K.G. Doucet *, K. Vaughan and J.F. Glister. Presented at the poster session of the Biological and Medicinal Chemistry Symposium, at the 89th Canadian Chemistry Conference and Exhibition of the Canadian Society of Chemistry, Halifax, Nova Scotia, May 27-31, 2006.
“1,4,8,11-Tetra-[2-aryl-1-diazenyl]-1,4,8,11-tetraazacyclotetradecanes: Synthesis, and Characterization of the first tetrakis-Triazenes to be reported.” by Jeffery D. Clarke* and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 89th Canadian Chemistry Conference and Exhibition of the Canadian Society of Chemistry, Halifax, Nova Scotia, May 27-31, 2006.
“Synthesis of three new series of 1,4-bis-(2-aryl-1-diazenyl-)piperazines.” by Vanessa R. Little*, Naomi Hunter and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 89th Canadian Chemistry Conference and Exhibition of the Canadian Society of Chemistry, Halifax, Nova Scotia, May 27-31, 2006.
“Synthesis of two new series of 1-Aryl-4-(2-aryl-1-diazenyl-)piperazines.” by Karen L. Schurmann* and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 89th Canadian Chemistry Conference and Exhibition of the Canadian Society of Chemistry, Halifax, Nova Scotia, May 27-31, 2006.
"An Ab Initio Study of 5-(1-Triazenyl)imidazole, a Simple Structural Analogue of the Antineoplastic Agent Dacarbazine". by C.C. Pye, K.G. Doucet *, K. Vaughan and J.F. Glister. Presented at the graduate poster session of the Biological and Medicinal Chemistry Symposium, at the 2006 APICS/CIC Student Chemistry Conference, Sackville New Brunswick, 18-20th May, 2006.
“Synthesis of two new series of 1-Aryl-4-(2-aryl-1-diazenyl-)piperazines.” by Karen L. Schurmann* and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 2006 APICS/CIC Student Chemistry Conference, Sackville, New Brunswick, 18-20th May, 2006.
“1,4,8,11-Tetra-[2-aryl-1-diazenyl]-1,4,8,11-tetraazacyclotetradecanes: Synthesis, and Characterization of the first tetrakis-Triazenes to be reported.” by Jeffery D. Clarke* and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 2006 APICS/CIC Student Chemistry Conference, Sackville New Brunswick, 18-20th May, 2006. Award: The NSERC Representative Award - Best Undergraduate Poster Overall.
“Synthesis of three new series of 1,4-bis-(2-aryl-1-diazenyl-)piperazines.” by Vanessa R. Little*, Naomi Hunter and Keith Vaughan , Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, presented at the Undergraduate Student Poster Session of the Organic Chemistry Symposium, at the 2006 APICS/CIC Student Chemistry Conference, Sackville, New Brunswick, 18-20th May, 2006. Award: 2nd Place Undergraduate Organic Poster.
“Synthesis and Characterization of a Series of 3-Methyl-3-{3-[1-methyl-3-aryl-3-triazenyl]propyl}-1-aryl-1-triazenes {1,3-Di-[1-aryl-3-methyltriazen-3-yl-]propanediamines}” by Jeff Clarke * and Keith Vaughan , poster presented at the 2005 APICS/CIC Atlantic Undergraduate Chemistry Conference, Memorial University, St. John's, Newfoundland, May 12-14th, 2005 . Award: 2nd Place Undergraduate Organic Poster.
“Synthesis and Characterization of a Series of 2,5-dimethyl-1,4-di-[2-aryl-1-diazenyl]-piperazines” by Vanessa Renee Little * and Keith Vaughan , oral presentation at the 2005 APICS/CIC Atlantic Undergraduate Chemistry Conference, Memorial University, St. John's, Newfoundland, May 12-14th, 2005 . Award: 2nd Place Undergraduate Organic Oral Paper.
"An ab initio investigation of the thermodynamic stability of tetraazabicycloalkanes." by C.R. Corbeil* , K. Vaughan and C.C. Pye. Oral presentation at the Atlantic Student Chemistry Conference, Saint Mary's University, Halifax, NS, May 13-15th, 2004.
“Synthesis and Characterization of a series of 1-Methyl-4-[2-aryl-1-diazenyl] piperazines and a series of Ethyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates.” By Vanessa Rene Little* and Keith Vaughan , presented at the 2004 APICS/CIC Student Chemistry Conference, May 13-15th, 2004, at Saint Marys Umiversity, Halifax, N.S. Award: Winner of 1st place award in undergraduate organic chemistry division.
“New Triazene derivatives of (1,X)-Diazacycloalkanes. (Nuevos Derividado Triazenicos de (1,X)-Diazacicloalcanos)”.S.L. Moser, B. Peori, R. Tingley and K. Vaughan *. Oral presentation at the Vth Internatiuonal Congress of Chemistry and Chemical Engineering. Havana International Conference Center, October 18-22nd, 2004, Havana, Cuba.
This page last modified Monday, 09-Jan-2012 13:33:32 AST